No. Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 1 of 4 1. /MediaBox [0 0 612 792] If you have Crohn's disease or a history of bowel obstruction, discuss with a doctor or pharmacist about drug interactions with fiber supplements.. Non-woody sources are also viable sources of cellulose, although only woody plants and cotton are the main sources for microcrystalline cellulose used as a pharmaceutical excipient. As one of the most robust and efficient excipients, it tolerates high salt content, high temperature and is stable in a wide pH range. It . Molecular weight: Not Applicable 1.5. Apply today! The polymers added organosolubility further creates advantages for employing HPMC in solvent spray-drying applications. };khd5x=fr In large quantities it provides dietary bulk and may lead to a laxative effect. 0.25 - 0.37. *r_ *?~4$ &0Y# In extrusion-spheronisation, it is the excipient of choice. This grade of polymer film remains intact at pH< 6, thus protecting the API in gastric environments. Comments: The human studies including the use of radiolabelled microcrystalline cellulose show complete absence of digestion or absorption. /Producer(Sub Systems, Inc.)/CreationDate(D:20181207095625+05'00')/ModDate(D:20181207095625+05'00')/Creator(Sub Systems, Inc.) >> Studies from the World Health Organisation and the European Food Safety Agency have concluded that Microcrystalline cellulose has no safety concerns for the public when used in animal nutrition. Well-recognized product that can do it all. F. Steele, M. Tobyn, S. Edge, A. Chen & J. N. Staniforth.Physicochemical and Mechanical Evaluation of a Novel High Density Grade of Silicified Microcrystalline Cellulose, Drug Development and Industrial Pharmacy, 30:1 (2004), 103-109. It is a white, free-flowing powder. Explore our end markets, products, ingredients and essential solutions or get in touch with us about your order. Biologicals by FMC. TEXTURECEL is highly purified sodium carboxymethyl cellulose (NaCMC) that forms clear solutions in water at all temperatures, has exceptional water binding properties, and is available in a wide range of viscosity grades. HMo@9, U Q!R/1*;` Further elaborations can then be performed on the obtained material to produce many other grades of Microcrystalline cellulose. These, in turn, are assembled into fibrils in the cell wall. Description: Microcrystalline Cellulose E460 is a term for refined wood pulp manufactured through plant fibre hydrolysis. Microcrystalline cellulose is produced by subjecting to a high shear treatment, at elevated temperature and pressure, a reaction mixture of a cellulose material, an active oxygen compound and water, for a time effective to depolymerize the cellulose material. Safety Data Sheet for Cellulose microcrystalline 102331. Enter your [postal] code to see information about local products, representatives and retailers, along with special offers in your area. Avicel Microcrystalline cellulose occurs as a white, odourless, tasteless, fibrous powder composed of porous particles. Product Specifications: Chemical and Physical: Loss on drying, % NMT 6.0* Viscosity, cps, 1.2% solids, 120 sec 39 to 91 . A., and Smith, P. A. Performing this action will revert the following features to their default settings: Hooray! The substance identifiers displayed in the InfoCard are the best available substance name, EC number, CAS number and/or the molecular and structural formulas. Manufacturer: FMC BioPolymer. Copyright 2023 by International Flavors & Fragrances Inc. IFF is a Registered Trademark. stream Chemsrc provides Cellulose microcrystalline(CAS#:9004-34-6) MSDS, density, melting point, boiling point, structure, formula, molecular weight etc. TEXTURECEL NaCMC is applied in oral solids, such as granules and pellets, powders as well as coatings for tablets. Microcrystalline Cellulose (MCC) MSDS 1. As some of the data above show, microcrystalline cellulose possesses unique physicochemical properties that set it apart from native cellulose. Avicel Microcrystalline cellulose is composed of insoluble fibre and does not contribute any other material of nutritional importance. Microcrystalline cellulose was negative in the Ames mutagenicity assay [FMC Study Number I91-1189], and caused no : 9004-34-6 Date Approved: 01/31/2008 . The most. Interestingly, the discovery of Avicel was accidental, the team was attempting to break up hydrolysed cellulose using a Waring Blender. /PRNewswire/ -- ReportsnReports added Global Microcrystalline Cellulose (MCC) Market Growth 2019-2024 to its online research database. : 5 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication Standard, 29 CFR 1910.1200 and Canadas Workplace Hazardous Materials Information System (WHMIS) requirements. Explore our commitment to environmental, social, and corporate governance and discover how we are making an impact. cas:9004-36-8 msds CELLULOSE ACETATE BUTYRATE. Product name: Microcrystalline cellulose; CBnumber: CB4217972; CAS: 9004-34-6; EINECS Number: 232-674-9; Synonyms: MICROCRYSTALLINE CELLULOSE,cellulose; pfTr^i5wOg)y .6 68ZWN hZB{u7ps@uWm 2#@+o/Z {vd^qHe42)Xz[T|[6:q/ i0lGX*}L[7;SGS "lj@::4G[IN{ Manufactured by: China . <> Avicel CL-611 Microcrystalline Cellulose and Sodium Carboxymethylcellulose Manufacturer FMC Corporation Product code 103-B Revision date 2014 September 30 Language English. It is an excipient approved for use in pharmaceutical products and is also GRAS listed and accepted for use as a food additive in Europe and the United States and is included in the FDA Inactive Ingredients Database (oral: powders, suspensions, syrups, and tablets; topical & vaginal products). CeolusTM UF-702, MSDS No.060EU MATERIAL SAFETY DATA SHEET NTP: Not listed ACGIH: Not listed 12. Molecular Weight null. IDENTIFICATION OF THE SUBSTANCE/PREPARATION AND THE COMPANY/UNDERTAKING Material Name: Estradiol Tablets Trade Name: RONFASE . Cellulose microcrystalline MSDS (material safety data sheet) or SDS, CoA and CoQ, dossiers, brochures and other available documents. Stabilizer composition of co-attrited microcrystalline cellulose and carboxymethylcellulose, method for making, and uses CN103842425B . LATTICE Microcrystalline Cellulose by Dupont, is an alpha cellulose obtained from naturally ocurring cellulose found in wood pulp, which is an equal structuring polysacharide that is found on fruits and vegetables. PDF (2.77 mb) 2021 FMC Sustainability Report. Fiber supplements can lessen the absorption of some . Some substance identifiers may have been claimed confidential, or may . Microcrystalline Cellulose (MCC) Manufacturing Industry. . Synergies to simplify formulation challenges and reduce operational costs. Description:Chemical PropertiesMicrocrystalline cellulose is a purified, partially depolymerized cellulose that occurs as a white, odorless, tasteless, crystalline powder composed of porous particles. Thus, Avicel contributes no or very few calories to the food system. Molecular weight: Not Applicable 1.5. FMC Corporation. It is highly versatile and is therefore also widely used in topicals and semi-solid & liquid dosage forms, including ointments, creams, gels, pastes, solutions, suspensions, and emulsions. Looking for FMC'searnings news? CAS 9004-34-6, pH 5 - 7.5. The table below lists the typical nutritional information of microcrystalline cellulose: Quantitative nutritional analysis of Avicel Microcrystalline cellulose (in 100g)1. Microcrystalline cellulose (MCC) is a pure partially depolymerized cellulose synthesized from -cellulose precursor (type I), obtained as a pulp from fibrous plant material, with mineral acids using hydrochloric acid to reduce the degree of polymerization. <> q9;v80q>jZ }[eD-1-8$#Yi^$o8Nc6vwfw;wBT~[Rgi1?%T*/J:/'+Gf'Ae*j@{Rh+2oN|Sbtt;z#v8})F#z=:*]q+U>+ .e ^Q-{@ RPC t/(If>8P&%wNPMJw,VI2aUqRqe3bC,a;C&4RQSf*(=I$r{'%jmk1LUZV(*is6r&wQPAAoID4p?,"lp:wE+)v(_w 'yelVnMh=gIYjK:9v{$G;b8=lGG1_,h^0F2`a~Kusz1p#NS*qt6,F:7+Rma-4u} DINFzJ"Mlctg*~HEge Microcrystalline cellulose is a commonly used excipient in the . Avicel is one of the best-known pharmaceutical excipient brands and, without doubt, one of the most frequently used raw materials in solid oral product formulation and manufacture. Protect them from sunshine or rain. Microcrystalline cellulose (Avicel, FMC Corporation) is prepared by acid hydrolysis of cellulose using 2 M hydrochloric acid at 105 C for 15 min. Dupont acquired the microcrystalline cellulose business of FMC Corporation in 2017. The highly reactive amorphous regions selectively hydrolyze, releasing the crystallites, which are subsequently mechanically dispersed. Tel: 1-239-598-5088 sales@espllc.us www.espllc.us. !,K`I[O@U|$+i 8sB|+"B@'2^7[2XKrd#5b The table below lists the most important chemical identifiers applicable to Avicel Microcrystalline cellulose. Alginates also function as actives in some anti-reflux products. pb7c8BHqCRX_eL +90w~ gk[YBkf9eDNJdNn q^16mi=4Sr0~{lZ>yvMqS'e,MqB?;Oy9s'$8asJgEh0SS>|J58ub^q c Dh)#t'kTfIZT1-_y"+wXj,qo!~ozc}ZemZ``$'vj{, Ga;]2iY*DIh~F3Z!.pkL:bHHBTbIcw9.Xo$4,?On4s=R,KLz /M|#PF(j%j oF2[5 ,rx)bd1$LM4Dc-d\@W D?A?L/7>s]-};Z if^+e3}AeQ# U%l3K?WW$iJ:tSS8M /&N2R3d2Nl2u]qg*WVkq2lhJZIiE++nKfq)sO~z(d| 7u4w!o}::#l}tEw'M}BEntaugq**t|KZUTe-1J+|. Aquacoat CPD is an aqueous dispersion of cellulose acetate phthalate used for enteric release applications. Ui[(lY[|//o)ZmqbQT-Y.M|se[)m?(WRV.W8J/j}9>X.VNsZNOp'^14nuXM%rea5]@ MKnNe Our customers around the world enjoy the benefits of TEXTURECEL NaCMC in various wound care products, too. Microcrystalline cellulose is a term for refined wood pulp and is used as a texturizer, an anti-caking agent, a fat substitute, an emulsifier, an extender, and a bulking agent in food production. Avicel PC 611 Microcrystalline Cellulose. AFFINISOL HPMC HME offers hot melt extrusion process flexibility in choosing a polymer viscosity that optimizes drug release profiles and against the factors affecting solubility. 1 0 obj Doses up to 30 g per day appear to be . II: effects of changes in the content of Microcrystalline Cellulose, AAPS PharmSci, 2 (2000) 45. Unique functionality for a broad range of pharmaceutical applications. 130. SDS - Safety Data Sheet. Microcrystalline Cellulose NF. BIOACCUMULATIVE POTENTIAL Alubra sodium stearyl fumarate from IFF Pharma Solutions is a comparatively hydrophilic lubricant widely used in capsule and tablet formulations. Remove There have always been two different points of view for the liquidity of MCC. bEI3%UxI"M_1)5b/c;/\~3:?/9S\\9/%I3nn2foO^MgX0n: O Of all the different brands and grades of MCC, Avicel PH 101 or Emcocel 50 has been the most widely used. <> Microcrystalline Cellulose; Cellulose; Functions. MATERIAL SAFETY DATA SHEET. The wood pulp is depolymerized by acid hydrolysis and turned from a fibrous material to a white freely-flowing powder. It is, however, a good source of fibre. 0.25 - 0.37. stream endstream METHOCEL products have been in continuous production for more than 70 years with production facilities and deep product expertise located around the globe. AFFINISOL HPMC has been specifically designed for generating solid dispersions via spray-drying (SDD) or hot melt extrusion (HME) in the pharmaceutical industry. Foam Booster/Stabilizer; Rheology Modifier; Stabilizer-Emulsion; Suspending Agent . }o]X4]. The global Microcrystalline Cellulose (Mcc) market size is projected to reach multi million by 2026, in comparison to 2022, at unexpected CAGR during 2022-2026. Same quality to grades 102/90M, but very low moisture content (< 1.5 %) for processing water-sensitive actives. This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication. With an account you can check out faster, view your online order history and access your shopping bag or saved items from any device. %PDF-1.4 The main source of cellulose is woody plants, since it is the main building block of the cell walls of higher plants. !(!0*21/*.-4;K@48G9-.BYBGNPTUT3? Eur., JPE . : 51395-75-6 Date Approved: 01/31/2008 Revision No. Avicel Microcrystalline Cellulose is a safe and non-hazardous material that is widely used in pharmaceutical formulations and food products (as a bulking agent and to add crispness). w !1AQaq"2B #3Rbr ]c\RbKSTQ C''Q6.6QQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQQ p@" Meet our leadership team. DC remains the most economical technique to produce large batches of tablets, however its efficacy is directly impacted by the raw material attributes. However, with many different grades (standard and specialty) on offer, how do you select the correct material for your needs? Microcrystalline cellulose 9004-34-6 <1 Synonyms are provided in Section 1. HAZARDS IDENTIFICATION EMERGENCY TELEPHONE NUMBERS (302) 451-0100 (FMC Plant - Newark, Delaware) (303) 595-9048 (Medical - U.S. - Call Collect) For leak, fire, spill, or accident emergencies, call: (800) 424-9300 (CHEMTREC - U.S.A. & Canada) (703) 527-3887 (CHEMTREC - Collect - All Other Countries) EMERGENCY OVERVIEW: Off-white, free-flowing, odorless powder. Are you sure you want to delete your template? endobj SUBSTANCE IDENTIFICATION 1.1. % SCMm_>x^O9l (n. Its used in capsules and tablets, both in wet granulation and direct compression processes, where it serves as a moisture adsorbent, tablet, and capsule diluent, and tablet disintegrant.It is also widely used as a supplementary formulation aid, primarily to enhance the . Microcrystalline Cellulose E460 MSDS 1. Hi, let us know if you have any questions as you visit our website. FMC Corporation 2929 Walnut Street Philadelphia, PA 19104 (215) 299-6000 (General Information) . More sophisticated drug discovery techniques have led to pipeline compounds that require solubility enhancement to be therapeutically effective. >> Instead, they obtained a stable colloidal suspension. It can be processed both via wet granulation and direct compression, as well as roller compression and extrusion-spheronisation. Earth Supplied Products LLC. q9;v80 % Product Name Cellulose microcrystalline. We are the leading manufacturer of Microcrystalline Cellulose coated with - RC 581 Grade in the industry. Truly distinctive drug delivery solutions. Document(s): certificate data msds. iq/iVO"5VI}dn.#q^(fJ),BN yb5*4reh1"!E?mR*%fK,e4?A\{OAXr1' tx&Ul{J,57n%PV E2eMS5'UOL wdD{s)4N-m ab K * ~CVHg}{J2.M}O)^}|Z{V+ >AW|? eqgP}OF'v7heLP&Y,eoo`x7lR}0iRVP],=`_2rS'*X$b)+XV2;fbQDgkgx:IZ|v>lDD/TDqz %RL Van Veen, G.K. Bolhuis, Y.S. XiDqLN MD'F2`jI7ZWu,JK%5e9~:R>LAm\WyY0lk=ZNP;pZ23)P0GG~%e[ d8GIXRo&. No. CAS #: 9004-34-6 . Htn@sHaYoEJ*H[G&o)o9;0s N'3[*%M]vAu#9Tqpg9D& However, if handling bulk powders, observance of appropriate safeguards is recommended. The representative usage of Avicel PH-101 and Avicel PH-102 Microcrystalline cellulose in wet granulation and direct compression is shown in the following two examples. Carboxymethyl Cellulose Sodium N/A Nutrition & Biosciences www.pharma.dupont.com HO 00017 - 0 E L 02.2020 www.dupontnutritionandbiosciences.com . MATERIAL SAFETY DATA SHEET Product Name: MICROCRYSTALLINE CELLULOSE Date/ Revised: 27/November/2012 Page 4 of 4 15. PROSOLV SMCC, silicified microcrystalline cellulose, is a unique combination of microcrystalline cellulose (MCC) and colloidal silicon dioxide (CSD).A high functionality and multifunctional excipient, it requires less complex processing, has high inherent functionality, and passes that functionality on to the drug formulation. % The current product range and recommended usage are summarised below: Microcrystalline Cellulose is currently listed in the United States Pharmacopoeia and National Formulary, the European Pharmacopeia, the Japanese Pharmacopoeia, the British Pharmacopoeia, in addition to the Indian and Chinese Pharmacopeia, to name but a few. Catalog Number 102331. 6 0 obj EMCOCEL 90 M. 130. By producing Avicel . PharmaCentral 2021 . endobj 2008-2023 ChemPoint. Aquacoat ECD is an aqueous dispersion of ethylcellulose used for sustained release barrier or slow release pharmaceutical coating, moisture barrier and taste masking applications for tablet and multi-particulate dosage forms. Combines good flow and high compactibility. All Rights Reserved. Avicel Microcrystalline Cellulose: Chemical Identifiers. SEM micrographs of microcrystalline cellulose (MCC) models with a scale bar of 100 m [1] . on Avicel microcrystalline cellulose, the most trusted excipient brand for decades. /Type/Page Microcrystalline Cellulose / Avicel PH-102. : 9 This document has been prepared to meet the requirements of the U.S. OSHA Hazard Communication . ChemicalBook. The typical mean particle size is 20200 m. Cellulose microcrystalline Revision Date 25-Dec-2021 SARA 313 Not applicable SARA 311/312 Hazard CategoriesSee section 2 for more information CWA (Clean Water Act) Not applicable Clean Air Act Not applicable OSHA - Occupational Safety and Health Administration Not applicable CERCLA Not applicable California Proposition 65 This product contains the following Proposition 65 chemicals.
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