Phentermine is not a miracle drug taken daily and the body simply starts losing weight all by itself. ). Use of Phentermine is contraindicated during or within 14 days following the administration of monoamine oxidase inhibitors because of the risk of hypertensive crisis. More specifically, this medication is an option for people with a body mass index (BMI): Greater than 30 kg/m2 Greater than 27 kg/m2 + one or more weight-related condition Sign up for free, and stay up to date on research advancements, health tips and current health topics, like COVID-19, plus expertise on managing health. ]^Ng8\!HqX 'nR l# w! {A6.q=0G: S:nR-`\ |%Tx F5z :^EU\)|\eyt0F Trends in Prescribing and Dispensing Patterns . other information we have about you. At January's meeting, the board discussed the rules and elected to investigate what other states are doing to regulate weight loss medication. This site complies with the HONcode standard for trustworthy health information: verify here. Copyright 2023 IBM Watson Health. endstream endobj 108 0 obj <>stream Last updated on Mar 22, 2022. Phentermine is one of the substances that have been researched thoroughly, thus its effects have been proven effective and the claims that are made about this drug are backed by scientific evidence. Phentermine, an amphetamine congener, is the most widely used anti-obesity drug in the U.S. In some cases, the side effects were life-threatening and led to the death of a patient. Phentermine is pregnancy category X, so it should never be taken while pregnant or nursing ( If not, additional education or an additional certification may be needed. In general, dose selection for an elderly patient should be cautious, usually starting at the low end of the dosing range, reflecting the greater frequency of decreased hepatic, renal, or cardiac function, and of concomitant disease or other drug therapy. Carefully follow your doctor's instructions for a reduced-calorie diet plan and regular exercise. Manifestations of acute overdosage include restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, and panic states. Like other weight-loss medicines ordered by providers, phentermine is meant to be only part of a weight-loss plan. Phentermine is for people with obesity or overweight who haven't been able to lose enough weight with diet and exercise alone to improve their health. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes. Before starting with consumption of this medication, patients should get informed about potential adverse effects to be able to determine whether a newly-developed symptom is a sign of a health issue or just a side effect associated with Phentermine. % Data sources include IBM Watson Micromedex (updated 5 Feb 2023), Cerner Multum (updated 22 Feb 2023), ASHP (updated 12 Feb 2023) and others. the current rules place time limitations on prescriptions that, many times, force physicians to stop a medication that is showing positive weight loss results. More, these sites also operate pharmacies that are not VIPPS-accredited, so you may also be putting your personal information and or money at-risk ( The safety and efficacy of combination therapy with Phentermine and any other drug products for weight loss including prescribed drugs, over-the-counter preparations, and herbal products, or serotonergic agents such as selective serotonin reuptake inhibitors (e.g., fluoxetine, sertraline, fluvoxamine, paroxetine), have not been established. Other brands of this drug include Suprenza, Phentercot, Acxion, Elvenir, Terflamex, Panbesy, Duromine, Fentermina, Phentermin, PHentermine and Lomaira. 1-612-816-8773. It is not uncommon for patients to experience a change in their sexual interest. The combined drug is approved for long-term use. , The dosage may be adjusted to the patients need. To provide you with the most relevant and helpful information, and understand which The structural formula is as follows: Phentermine hydrochloride is a white, odorless, hygroscopic, crystalline powder which is soluble in water and lower alcohols, slightly soluble in chloroform and insoluble in ether. Dosage should be individualized to obtain an adequate response with the lowest effective dose. RPYcn@b[%XYK'Q %[.()GTkJ WCf.-i>n-oIzE*D40f#Gp'LcddmE8;>u?X"tO 1]M={4,ReC8E8Z Q1Lt$-XpFCrTJ IBM Micromedex. 5 Dr. Lazarus, we will discuss combination phentermine therapy later in this roundtable discussion. Rule 4731-11-04 | Controlled substances: Utilization of short term anorexiants for weight reduction. Studies do not permit conclusions as to the relative importance of the drug and non-drug factors on weight loss. In order to help patients reduce their risk of developing these diseases when they are obese, doctors usually prescribe Phentermine. Phentermine is contraindicated during pregnancy because weight loss offers no potential benefit to a pregnant woman and may result in fetal harm. With respect to the care and treatment of patients with obesity, APRNs are required to incorporate the State Medical Board rules applicable to physicians and prescribing practices. Specializes in NICU, PICU, Transport, L&D, Hospice. This medication has been linked to physical dependence, which means a patient may become addicted to it. The most common brand of Phentermine is a product known as Adipex, but officially called Adipex-P. The medical board is currently reviewing its long-standing rules regarding prescribing controlled substances for the treatment of obesity. Today, Phentermine can still be obtained through the doctors prescription in the majority of countries around the world. Accessed Oct. 11, 2022. Serious regurgitant cardiac valvular disease, primarily affecting the mitral, aortic and/or tricuspid valves, has been reported in otherwise healthy persons who had taken a combination of Phentermine with fenfluramine or dexfenfluramine for weight loss. 4 N;d0)zQ|,]8EtXy(En"GX omjU3Y3>kfkYHYi]-zhm{= o`i$G1BK%?9Z+(dm`mKt,?;6K@Q 7}}*Tw>7BkKsJ;E|Viexb T-3j%5QB%wI5'$5oB :h*C"Q7yjTzLO%6QS/u>HX 4DGz*A!1*p"7$-joX2YF8ht@\l[&LS$FU=udM&y.l_ The FDA in the United States first approved the use of Amphetamine as a drug that can be used to suppress a patients appetite in 1959. Common side effects of phentermine include: Phentermine is one of the most prescribed weight-loss medicines. It is contraindicated for patients with current or past: cardiovascular disease (heart problems), hyperthyroidism, glaucoma, agitated states, drug/alcohol abuse, or reactions to sympathomimetic amines. A total of 24 patients developed heart valve disease while taking this drug, which led the FDA to withdraw the product from the market in 1997. hYr ~{L(QdK4^bdsO_d;a BXO--p,!4!,WhfM/@c ), Cannot find a doctor in your network that prescribes phentermine. If your dose is different, do not change it unless your doctor tells you to do so. Avoid use of Phentermine in patients with eGFR less than 15 mL/min/1.73m2 or end-stage renal disease requiring dialysis [see Use in Specific Populations (8.6) and Clinical Pharmacology (12.3)]. %PDF-1.6 % Unfortunately, the answer is no in most cases. Phentermine hydrochloride: Usual dosage is 8 mg 3 times daily (given 30 minutes before meals) or 15-37.5 mg once daily (in the morning). Phentermine is intended to help overweight and obese patients who have already tried losing weight with diet and exercise. The first use of Phentermine as a drug to help treat obesity dates back to 1938. Dryness of the mouth, unpleasant taste, diarrhea, constipation, other gastrointestinal disturbances. You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. %PDF-1.3 Do You Need a Prescription for Phentermine? Some weight loss clinics also insist that patients take additional supplements, such as vitamin B12 shots and 5-HTP, to boost phentermine despite the supplements unproven effectiveness. The rate of weight loss is greatest in the first weeks of therapy for both drug and placebo subjects and tends to decrease in succeeding weeks. However, the medication does have a considerable street value. What could be the cause? The dose of this medicine will be different for different patients. While these are the most common side effects of the drug, they are not the only consequences associated with the intake of this medication. Phentermine is 17.5% plasma protein-bound, while topiramate is 15 - 41% plasma protein-bound when the blood concentration range is 0.5 to 250 g/mL. He or she may prescribe the medication him/herself if you are an appropriate candidate, or he/she may choose to refer you to a specialist for further evaluation and follow-up. The patient brings in a prescription for the same drug on November 1, 2013. It is a class IV controlled substance because of its serious side effects and addiction potential. The medication has been classified as a controlled substance in most countries and is also classified as a schedule IV prescription drug. It is freely soluble in water; sparingly soluble in warm alcohol, insoluble in chloroform, acetone, ether and benzene. The possible origins of the increased weight loss due to the various drug effects are not established. After the tablet has melted, swallow or take a sip of water. Keep from freezing. privacy practices. Implementation of the Ryan Haight Online Pharmacy Consumer Protection Act of 2008. Perreault L. Obesity in adults: Drug therapy. Taking more than the prescribed amount of Phentermine can lead to an overdose, which means if a patient misses a dose, they should never try to make up for it by taking more than the prescribed amount at the next dose. The board expressed concerns that removing the prescribing restrictions could lead to misuse of weight loss drugs such as phentermine. The possibility of an association between valvular heart disease and the use of Phentermine alone cannot be ruled out; there have been rare cases of valvular heart disease in patients who reportedly have taken Phentermine alone. hb```e````a`d`@ f(fcfILLvL~. The natural history of obesity is measured over several years, whereas the studies cited are restricted to a few weeks duration; thus, the total impact of drug-induced weight loss over that of diet alone must be considered clinically limited. "Mayo," "Mayo Clinic," "MayoClinic.org," "Mayo Clinic Healthy Living," and the triple-shield Mayo Clinic logo are trademarks of Mayo Foundation for Medical Education and Research. Any use of this site constitutes your agreement to the Terms and Conditions and Privacy Policy linked below. If this drug is used during pregnancy, or if the patient becomes pregnant while taking this drug, the patient should be apprised of the potential hazard to a fetus. Tell patients to keep Phentermine in a safe place to prevent theft, accidental overdose, misuse or abuse. (5) A treatment plan based upon the clinical information obtained, to include all of the following components: (a) Diagnosis; (b) Objective goals for treatment; (c) Rationale for the medication choice and dosage; and (d) Planned duration of treatment and steps for further assessment and follow-up. The magnitude of increased weight loss of drug-treated patients over placebo-treated patients is only a fraction of a pound a week. Ask your healthcare professional how you should dispose of any medicine you do not use. Six years after the approval, a similar drug, called Aminorex, were released in Europe with the same purpose of helping obese individuals. Check out these best-sellers and special offers on books and newsletters from Mayo Clinic Press. (1981, February 4). If your primary care physician thinks you are a good candidate for phentermine but does not want to (or cannot) prescribe it, he or she may refer you to a specialist. LZ(6&JQKU5@5_M.~#p = yLgzP"Z90* v~1iu0pV (s:J&Q,. } }& 8}q>u@y)dO|fRmknw huA0@6-%&k-1qI6fSt4#>=sHMk>8fztq9_ nw:>NxHfib Lx.c QEWg\@y@ ~[*+-Dze~Ej+%.E`|IdW#o~#` MM You'll soon start receiving the latest Mayo Clinic health information you requested in your inbox. Each tablet contains the following inactive ingredients: starch, lactose anhydrous, microcrystalline cellulose, colloidal silicon dioxide, stearic acid, magnesium stearate and blue sugar spheres.
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