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what does chromosome 2 determine

Direct link to Gabby Merritt's post Cohesion or cohesive attr, Posted 4 years ago. The structure and location of chromosomes are among the chief differences between viruses, prokaryotes, and eukaryotes. A ring chromosome refers to the formation of a circular chromosomewhen the ends of a chromosome break and join together. Omissions? These chromosomes are tightly packed inside the nucleus of a cell and are made of DNA molecules. Image of a eukaryotic cell, showing the nuclear DNA (in the nucleus), the mitochondrial DNA (in the mitochondrial matrix), and the chloroplast DNA (in the stroma of the chloroplast). Another syndrome caused by imbalance in the number of sex chromosomes is Turner syndrome. They have only one sex determining chromosome, and that can be x or y. The unique structure of chromosomes keeps DNA tightly wrapped around spool-like proteins, called histones. A fruit fly, for example, has four pairs of chromosomes, while a rice plant has 12 and a dog, 39. Some mutations remove genetic material from the long arm of chromosome 2. The base pairs are the DNA building blocks and are tightly packed, coiled, and supercoiled to form the structure of the DNA helix. For complete list, see the link in the infobox on the right. G-banding ideogram of human chromosome 14 in resolution 850 bphs. In this article, News-Medical talks to Sartorius about biosensing and bioprocessing in gene therapy, . So CCDS's gene number prediction represents a lower bound on the total number of human protein-coding genes.[14]. The centromere is the point of attachment of the kinetochore, a protein structure that is connected to the spindle fibres (part of a structure that pulls the chromatids to opposite ends of the cell). This cell then divides and its successors divide numerous times, eventually producing a mature individual with a full set of paired chromosomes in virtually all of its cells. It is also unknown whether the loss or gain of other genes in chromosome 2 deletions or duplications contribute to the features of MAND. One such method is called noninvasive prenatal testing. I don't know about human eye colour, but proteins carry out many functions in the body, from regulating what gets into or out of the cell, keeping the cell's structure, and catalysing reactions that make other molecules in the cell (this is the job of enzymes). "Search results - 14[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene", Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3), "Between a chicken and a grape: estimating the number of human genes", "Statistics & Downloads for chromosome 14", "Chromosome 14: Chromosome summary - Homo sapiens", "Human chromosome 14: entries, gene names and cross-references to MIM", "Search results - 14[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene", "Search results - 14[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene", "Search results - 14[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene", "Concerted regulation of myofiber-specific gene expression and muscle performance by the transcriptional repressor Sox6", Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3), Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3), "Estimation of band level resolutions of human chromosome images", "The DNA sequence and analysis of human chromosome 14", 10.1002/(SICI)1096-8628(19991203)87:4<294::AID-AJMG2>3.0.CO;2-S, https://en.wikipedia.org/w/index.php?title=Chromosome_14&oldid=1133388512, This page was last edited on 13 January 2023, at 14:57. Do males have different chromosomes than females. Radionenko M, Waligorski JE, Wang C, Rock SM, Tin-Wollam AM, Maupin R, Latreille with these terms and conditions. News-Medical. The mother and father each contribute one set of 22 autosomes and one sex chromosome. Chromosomes vary in number and shape among living things. This organizes and condenses the DNA, I believe this is for when the chromosomes duplicate. Eur J Med Genet. How does that work for the body? The cause of the skeletal abnormalities and other non-neurological features of MAND is unclear. In most animals, however, any change from the typical chromosome number for a species may be accompanied by changessometimes drasticin the organism. Proteins that play a role in neurological functions are particularly affected, which helps explain why MAND impacts brain development and behavior. Most features of MAND are due to the loss or gain of one copy of the MBD5 gene. Wikipedia, Do you add haploid cells to a set of cells in the nucleus, I believe there is an error to this lesson. To log in and use all the features of Khan Academy, please enable JavaScript in your browser. The following are some of the gene count estimates of human chromosome 14. As a real example, let's consider a gene on chromosome 9 that determines blood type (A, B, AB, or O) ^2 2. Prior Knowledge Question (Do this BEFORE using the Gizmo.) Somatic cells reproduce by dividing, a process called mitosis. Chromosome 2 deletions or duplications that cause MAND lead to an abnormal amount of MBD5 protein. One widely accepted theory is that chromosome 2 was formed by the fusion of two ancestral chromosomes. The comparison can be used to find chromosomal abnormalities where the two samples differ. MBD5 locus. Robertson, Sally. News-Medical, viewed 04 March 2023, https://www.news-medical.net/health/What-is-Chromosome-2.aspx. Nature. Because researchers use different approaches to predict the number of genes on each chromosome, the estimated number of genes varies. Direct link to Bushi's post chroma means colored and , Posted 6 years ago. What is the difference between N (number of chromosome sets) and C (number of chromosome copies)? Heller M, Provan D, Amess JA, Dixon-McIver A. Myelodysplastic syndrome Image of the karyotype of a human male, with chromosomes from the mother and father false-colored purple and green, respectively. DNA packaging into chromatin and chromosome. Each chromosome is made of protein and a single molecule of deoxyribonucleic acid (DNA). In fruit flies, which normally have red-brown eyes, there are mutants with white eyes with mutations in a transporter which means a precursor for certain pigments can't enter the cell. A fruit fly, for example, has four pairs of chromosomes, while a rice plant has 12 and a dog, 39. Like a recipe book, each chromosome contains a certain number of recipes, known as ' genes '. You will need to look at the letters from chromosomes 12, 13, 14, and 15 to determine the eye color. In most cases, females have two of the same kind of . 2005 Aug;27(4):270-3. doi: This is so that when the sex cells fuse together during fertilization, a complete diploid set is formed. They protect the ends of chromosomes in a manner similar to the way the tips of shoelaces keep them from unraveling. DNA is also passed on at the level of organisms, with the DNA in sperm and egg cells combining to form a new organism that has genetic material from both its parents. The shorter arm is called the "p" arm. Chromosome 2 contains the HOXD homeobox gene cluster. The regions on either side of the centromere are referred to as the chromosome's arms. Histone also play a part in gene activity. myelodysplastic syndromes and acute myeloblastic leukemias. Direct link to Sean Cozart's post So cells go under mitosis, Posted 7 years ago. Partial list of the genes located on p-arm (short arm) of human chromosome 2: Partial list of the genes located on q-arm (long arm) of human chromosome 2: The following diseases and traits are related to genes located on chromosome 2: G-banding ideograms of human chromosome 2. Morgan made the link between chromosomes and inherited traits by demonstrating that the X chromosome is related to gender and eye color in fruit flies. Inherited 2q23.1 microdeletions involving the As chromosomes are copied in preparation for production of a new cell, the centromere serves as an attachment site for the two halves of each replicated chromosome, known as sister chromatids. Learn how and when to remove this template message, Hereditary nonpolyposis colorectal cancer, Infantile-onset ascending hereditary spastic paralysis, Long-chain 3-hydroxyacyl-coenzyme A dehydrogenase deficiency, Mitochondrial trifunctional protein deficiency, "Search results - 2[CHR] AND "Homo sapiens"[Organism] AND ("has ccds"[Properties] AND alive[prop]) - Gene", Ideogram data for Homo sapience (850 bphs, Assembly GRCh38.p3), "Generation and annotation of the DNAD sequences of human chromosomes 2 and 4", Vega Homo sapiens genome browser: HoxD cluster on Chromosome 2, "A high-coverage genome sequence from an archaic Denisovan individual", It has been hypothesized that Human Chromosome 2 is a fusion of two ancestral chromosomes, "Chromosome 2 in the Great Apes - YouTube", "Origin of human chromosome 2: an ancestral telomere-telomere fusion", "Between a chicken and a grape: estimating the number of human genes", "Statistics & Downloads for chromosome 2", "Chromosome 2: Chromosome summary - Homo sapiens", "Human chromosome 2: entries, gene names and cross-references to MIM", "Search results - 2[CHR] AND "Homo sapiens"[Organism] AND ("genetype protein coding"[Properties] AND alive[prop]) - Gene", "Search results - 2[CHR] AND "Homo sapiens"[Organism] AND ( ("genetype miscrna"[Properties] OR "genetype ncrna"[Properties] OR "genetype rrna"[Properties] OR "genetype trna"[Properties] OR "genetype scrna"[Properties] OR "genetype snrna"[Properties] OR "genetype snorna"[Properties]) NOT "genetype protein coding"[Properties] AND alive[prop]) - Gene", "Search results - 2[CHR] AND "Homo sapiens"[Organism] AND ("genetype pseudo"[Properties] AND alive[prop]) - Gene", "Largest Ever Autism Study Identifies Two Genetic Culprits", "Cleft Chin | AncestryDNA Traits Learning Hub", "Lowry-Wood syndrome: Further evidence of association with RNU4ATAC, and correlation between genotype and phenotype", "Photic Sneeze Reflex | AncestryDNA Traits Learning Hub", Ideogram data for Homo sapience (400 bphs, Assembly GRCh38.p3), Ideogram data for Homo sapience (550 bphs, Assembly GRCh38.p3), https://en.wikipedia.org/w/index.php?title=Chromosome_2&oldid=1138449158, The correspondence of chromosome 2 to two, This page was last edited on 9 February 2023, at 19:25. These different forms are called alleles, which are positioned on . This is a test to screen a pregnancy to determine whether a baby has an increased chance of having specific chromosome disorders. A structural abnormality means the chromosome's structure has been altered in one of several ways. Brick L, Li C, Dupuis L, Rosello M, Aradhya S, Stavropoulos DJ, Manickam K, This site complies with the HONcode standard for trustworthy health information: verify here. In Turner syndrome, a female is born with only one sex chromosome, an X, and is usually shorter than average and unable to have children, among other difficulties. Direct link to 001303405's post how do we identify studen, Posted a month ago. Chromosome abnormalities usually occur when there is an error in cell division. Females have two X chromosomes in their cells, while males have one X and one Y. 2= diploid has, Posted 3 years ago. Direct link to Macie's post The general concept of mi, Posted 7 years ago. More info. As long as the sister chromatids are connected at the centromere, they are still considered to be one chromosome. chromosome 2 and microdeletion of 2q detected using FISH: Further support for News-Medical.Net provides this medical information service in accordance By continuing to browse this site you agree to our use of cookies. For example, if you have . Mitosis results in two cells that are duplicates of the original cell. No abstract The X and Y chromosomes, also known as the sex chromosomes, determine the biological sex of an individual: females inherit an X chromosome from the father for a XX genotype, while males inherit a Y chromosome from the father for a XY genotype (mothers only pass on X chromosomes). This disease affects the blood and bone marrow. Two copies of chromosome 15, one copy inherited from each parent, form one of the pairs. It actually comes from the fact that chromosomes can easy accept/take up dye. on this website is designed to support, not to replace the relationship Humans and most other mammals have two sex chromosomes, X and Y, that in combination determine the sex of an individual. also, are the histones? Chromosome 15 spans more than 102 million DNA building blocks (base pairs) and represents more than 3 percent of the total DNA in cells. An individual with Down syndrome has three copies of chromosome 21 rather than two; for that reason, the condition is also known as Trisomy 21. This is the way most of the cells that make up our body are made and replaced. Mullegama SV, Rosenfeld JA, Orellana C, van Bon BW, Halbach S, Repnikova EA, Zondag S, Toriello HV, Magenis RE, Elsea SH. For instance, the 46 chromosomes found in human cells have a combined length of 200 nm (1 nm = 10 9 metre); if the chromosomes were to be unraveled, the genetic material they contain would measure roughly 2 metres (about 6.5 feet) in length. They are called sex chromosomes: Females have 2 X . Sex chromosomes determine an individual's sex: females have two X chromosomes (XX), and males have an X and a Y chromosome (XY). Can changes in the structure of chromosomes affect health and development? The chromosome consists of a single chromatid and is decondensed (long and string-like). The cell divides, and both of the daughter cells have a complete (diploid) set of chromosomes. What kind of chromosomes do all living things have? One molecule of DNA and one protein make up one chromosome. To help identify chromosomes, the pairs have been numbered from 1 to 22, with the 23rd pair labeled "X" and "Y." But, the text does not discuss how any cell dies. In eukaryotes such as plants and animals, the majority of DNA is found in the nucleus and is called, In a cell, DNA does not usually exist by itself, but instead associates with specialized proteins that organize it and give it structure. "What is Chromosome 2?". Do all living things have the same types of chromosomes? We use cookies to enhance your experience. Updates? Stevens-Kroef M, Poppe B, van Zelderen-Bhola S, van den Berg E, van der So cells go under mitosis and meiosis. Yes - red blood cells are enucleated to make more space for hemoglobin, the protein that binds to oxygen. Older women are at higher risk of giving birth to babies with chromosome abnormalities than younger women. Numerical Abnormalities: When an individual is missing one of the chromosomes from a pair, the condition is called monosomy. A patient with a ring Chromosome 9 likely contains 800 to 900 genes that provide instructions for making proteins. Retrieved on March 04, 2023 from https://www.news-medical.net/health/What-is-Chromosome-2.aspx. While every effort has been made to follow citation style rules, there may be some discrepancies. Changes in chromosome 2 have been identified in several types of cancer. The techniques that were honed at a later date to obtain colored band and interband patterns in chromosomes revealed that our second largest chromosome is the result of a fusion of two chromosomes belonging to our closest evolutionary ancestors. Your body has many different kinds of cells, such as skin cells, liver cells and blood cells. They also contain RNA. If you're behind a web filter, please make sure that the domains *.kastatic.org and *.kasandbox.org are unblocked. Genes are the individual instructions that tell our bodies how to develop and function; they govern physical and medical characteristics, such as hair color, blood type and susceptibility to disease. Direct link to 23ancap1's post what are chromosomes made, Posted 2 years ago. Image of a cell undergoing DNA replication (all the chromosomes in the nucleus are copied) and chromosome condensation (all the chromosomes become compact). Passed from parents to offspring, DNA contains the specific instructions that make each type of living creature unique. While the size of the deletion varies among affected individuals, it always contains a certain gene, called HDAC4. Molecular cytogenetic analysis of five 2q37 deletions: refining the Changes in chromosome 2 have been shown to lead to several forms of cancer. In the center of most cells is a structure called the nucleus. What is Chromosome 2?. See also polyploidy. This article was most recently revised and updated by, https://www.britannica.com/science/chromosome, LiveScience - Chromosomes: Definition & Structure, Merck Manuals - Consumer Version - Genes and Chromosomes. Two copies of chromosome 2, one copy inherited from each parent, form one of the pairs. Am J Hum Genet. These newer methods compare the patient's DNA to a normal DNA sample. The severity of symptoms often depends on which types of cells are affected. Typically, biologically female individuals have two X chromosomes (XX) while those who are biologically male have one X and one Y chromosome (XY). This genetic information is found in the cytoplasm. Compilation of the top interviews, articles, and news in the last year. . A chromosome has many genes, a combination of genetic information that gives rise to characteristics, but it is only. Epub 2016 Oct 24. E, Hou S, Levy A, Martinka S, Mead K, McLellan MD, Meyer R, Randall-Maher J, After chromosome condensation, the chromosomes condense to form compact structures (still made up of two chromatids). In humans and most other complex organisms, one copy of each chromosome is inherited from the female parent and the other from the male parent. disorder. Clin Lab Haematol. The single chromosome of a prokaryotic cell is not enclosed within a nuclear membrane. Telomeres are repetitive stretches of DNA located at the ends of linear chromosomes. This type of ideogram is generally used in genome browsers (e.g. Genes are the individual instructions that tell our bodies how to develop and function; they govern physical and medical characteristics, such as hair color, blood type and susceptibility to disease. FISH. Czepulkowski B, Saunders K, Pocock C, Sadullah S. Mosaic trisomy 2 in The changes that occur are somatic, meaning they are acquired at some point throughout a persons lifetime rather than being present when a child is born (as inherited changes are). The chromosomes of a eukaryotic cell consist primarily of DNA attached to a protein core. Casas KA, Mononen TK, Mikail CN, Hassed SJ, Li S, Mulvihill JJ, Lin HJ, Falk Zarate YA, Fish JL. In these cases, the abnormality is present in every cell of the body. Errors can also occur when the chromosomes are being duplicated. 2q37 deletion syndrome occurs when genetic material is deleted from a specific region of chromosome 2, near the end of the long arm at location 2q37. Move on to chromosome #2. Different species have different numbers of chromosomes. The severity of symptoms typically depends on how many and which types of cells contain the ring chromosome 2. These images are then arranged to form a. Chromosome 2q terminal deletion: report of 6 new patients and review of Males with more than one X chromosome have Klinefelter syndrome, which is a condition characterized by tall stature and, often, impaired fertility. The concept of a fusion first came about in 1982 when scientists examined the similarities of human and ape chromosomes under a microscope. In addition, the bands that appear after staining are numbered; the higher the number, the farther that area is from the centromere. However, as soon as they are pulled apart during cell division, each is considered a separate chromosome. White blood cells and other cell types with the capacity to divide very frequently have a special enzyme that prevents their chromosomes from losing their telomeres. There is an equally great range of numbers among plants. Can changes in the number of chromosomes affect health and development? Available at: https://www.cancer.gov/types/myeloproliferative/patient/myelodysplastic-treatment-pdq#section/all (Accessed: 30 June 2022). Am J Med Genet A. In both processes, the correct number of chromosomes is supposed to end up in the resulting cells. Most people with MAND also have behavior problems similar to autism spectrum disorder, a developmental condition that affects communication and social interaction. chromosome number, precise number of chromosomes typical for a given species. These proteins perform a variety of different roles in the body. Scientists think that, in the past, mitochondria were free-living bacteria with the ability to convert oxygen into energy. The general concept of mitosis is one cell splitting into two. P, Wendl MC, Yang SP, Pohl C, Wallis JW, Spieth J, Bieri TA, Berkowicz N, Nelson The centromere of chromosome 14 is positioned approximately at position 17.2 Mbp. In addition to what Aleksandr has said here, you may also wish to consider that mature organs contain many cells which no longer reproduce, but simply serve their function until they die and are replaced. It is also crucial that reproductive cells, such as eggs and sperm, contain the right number of chromosomes and that those chromosomes have the correct structure. SH. Chromosomes are the structures that hold genes. Available at: https://www.cancer.org/healthy/cancer-causes/genetics/family-cancer-syndromes.html (Accessed: 30 June 2022). Within the primate family Hominidae, 24 pairs of chromosomes are seen in all species apart from humans and the extinct Neanderthals and Denisovan species, where 23 pairs of chromosomes make up the genome. 2004 Jun;41(6):433-9. doi: 10.1136/jmg.2003.017202. Band length in this diagram is proportional to base-pair length. An increase or decrease in MBD5 protein disrupts gene expression that is normally well-controlled by this protein, which is likely why duplications and deletions of this gene lead to the same signs and symptoms. Aldred MA, Sanford RO, Thomas NS, Barrow MA, Wilson LC, Brueton LA, Bonaglia 2017 Feb;173(2):327-337. doi: Examples of polyploid plants and animals are the potato (Solanum tuberosum), the African clawed frog (Xenopus laevis), and the plains viscacha rat (Tympanoctomys barrerae; also called red vizcacha rat). Supporting and even conclusive evidence exists for this theory. Other changes involving the number or structure of chromosome 2 include an extra piece of the chromosome in each cell (partial trisomy 2) or a missing segment of the chromosome in each cell (partial monosomy 2). Direct link to 231434's post how does DNA get to the c, Posted 7 years ago. . abstract available. For complete list, see the link in the infobox on the right. Among sexually reproducing organisms, the number of chromosomes in the body (somatic) cells is diploid (2 n; a pair of each chromosome), twice the haploid (1 n) number found in the sex cells, or gametes. This DNA is responsible for carrying the hereditary information. Still, mistakes do occur on rare occasions. Some abnormalities, however, happen after conception; then some cells have the abnormality and some do not. Direct link to keeyan000's post How many DNA are there in, Posted 7 years ago. 2003 Aug;145(1):78-81. doi: 10.1016/s0165-4608(03)00030-x. Sperm cells contain either an x chromosome or a y chromosome, not both. 10.1016/j.ajhg.2011.09.011. Chromosome 1 is the designation for the largest human chromosome.Humans have two copies of chromosome 1, as they do with all of the autosomes, which are the non-sex chromosomes.Chromosome 1 spans about 249 million nucleotide base pairs, which are the basic units of information for DNA. Hillier LW, Graves TA, Fulton RS, Fulton LA, Pepin KH, Minx P, and genotype-phenotype correlation. Deletions prevent one copy of the MBD5 gene in each cell from producing any functional protein, which reduces the total amount of this protein in cells. Image of a long, double-stranded DNA polymer, which wraps around clusters of histone proteins. G-banding patterns of human chromosome 14 in three different resolutions (400, For cytogenetic banding nomenclature, see article. J Med Genet. Changes to the structure of a chromosome or abnormalities in the number of chromosomes present can also cause health conditions and some of these are described below. Am J Med Genet C Semin Med Genet. Corrections? Or they may be smaller, removing material from within the SATB2 gene. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC52649/#:~:text=We%20conclude%20that%20the%20locus,rise%20to%20human%20chromosome%202, http://atlasgeneticsoncology.org/Anomalies/Tri2ID1429.html, PARK2 duplication or microdeletion and neurological diseases, Severity of COVID-19 in men may be due to the loss of Y chromosome, Non-invasive artificial intelligence approach for IVF embryo selection, Simple blood tests for telomeric protein could provide a valuable screen for certain cancers, Green tea may protect against telomere shortening due to biological aging, ACMG's new guideline strongly recommends the use of noninvasive prenatal screening for fetal chromosome abnormalities, Brain over-activation could be causing seizures and social deficits in genetic subtype of autism, Pathological significance of CEACAMS 1, 5, and 6 in cancer biology, immunology and inflammatory disease. Researchers gained a much better understanding of chromosomes in the early 1900s through Thomas Hunt Morgan's pioneering studies. Am J Med Genet A. Without such packaging, DNA molecules would be too long to fit inside cells. Direct link to ssloan0252's post create scenarios that all, Posted 2 years ago. Every eukaryotic species has a characteristic number of chromosomes (chromosome number). Physically speaking, DNA is a long string of paired chemical units (nucleotides) that come in four different types, abbreviated A, T, C, and G, and it carries information organized into units called. Humans normally have 46 chromosomes in each cell, divided into 23 pairs. Shouldn't it be "Genes make up DNA, DNA makes up chromosomes", . If your confused you should watch this video here: chroma means colored and soma means body. The MBD5 gene provides instructions for a protein that likely regulates the activity (expression) of genes, controlling the production of proteins that are involved in neurological functions such as learning, memory, and behavior. Normally, each cell in the human body has 23 pairs of chromosomes (46 total chromosomes). That's because you may have inherited two different gene versions from your mom and your dad. When a cell divides, one of its main jobs is to make sure that each of the two new cells gets a full, perfect copy of genetic material. The human genome includes 21,000 or so genes, spread out along 3 billion base pairs of DNA. A chromosomal karyotype is used to detect chromosome abnormalities and thus used to diagnose genetic diseases, some birth defects, and certain disorders of the blood or lymphatic system. For instance, in humans, fetuses affected by polyploidy often are spontaneously aborted early in pregnancy. If all the DNA inside one dog cell was laid out end to end, it would stretch over 6 feet in length. Humans, along with other animals and plants, have linear chromosomes that are arranged in pairs within the nucleus of the cell. Histones are bobbin shaped, positively charged, eukaryotic proteins. People normally have two copies of this chromosome. During fertilization, two gametes combine to produce a zygote, a single cell with a diploid set of chromosomes. Inversions: A portion of the chromosome has broken off, turned upside down, and reattached. MJ, Leheup B, Taine L, Lacombe D, Delrue MA, Toutain A, Paubel A, Mugneret F, If not, the resulting offspring may fail to develop properly. Telomeres also play a role in cancer. Contact a health care provider if you have questions about your health. Chromosomes are structures that look like thread, which live in the nucleus (center) of cells. Direct link to Austin592's post What is a cohesin? Finally, in humans, chromosome 2 telomeres are present at both the center and the ends, whereas usually telomeres are only found at the ends of a chromosome. See our, URL of this page: https://medlineplus.gov/genetics/chromosome/2/. Updates? Another chromosome 2 abnormality is known as a ring chromosome 2. Identifying genes on each chromosome is an active area of genetic research. Chromosomes are thread-like structures located inside the nucleus of animal and plant cells. It represents about 8% of the total DNA in human cells. For example, humans are diploid (2n) and have 46 chromosomes in their normal body cells. Chromosome 2 is the second-largest human chromosome, spanning more than 242 million base pairs [4] and representing almost eight percent of the total DNA in human cells .

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